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COMMUNICATIONS TO THE EDITOR
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779-783
| Discovery of 6-Oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinebutanoic Acid (FK 838): A Novel Non-Xanthine Adenosine A1 Receptor Antagonist with Potent Diuretic Activity
Atsushi Akahane,
Hirohito Katayama,
Takafumi Mitsunaga,
Takeshi Kato,
Takayoshi Kinoshita,
Yasuhiro Kita,
Takahiro Kusunoki,
Takao Terai,
Keizo Yoshida, and
Youichi Shiokawa
[Full Article -
PDF] |
784-787
| Acquisition of High-Affinity, SH2-Targeted Ligands via a Spatially Focused Library
Tae Ryong Lee and
David S. Lawrence
[Full Article -
PDF] |
788-790
| Studies on the Mode of Action of Mitomycin C(7) Aminoethylene Disulfides (BMS-181174 and KW-2149): Reactivity of 7-N-(Mercaptoethyl)mitomycin C
Shuang Wang and
Harold Kohn
[Full Article -
PDF] |
ARTICLES
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791-804
| A General and Fast Scoring Function for Protein-Ligand Interactions: A Simplified Potential Approach
Ingo Muegge and
Yvonne C. Martin
[Full Article -
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805-818
| Non-Peptide Corticotropin-Releasing Hormone Antagonists: Syntheses and Structure-Activity Relationships of 2-Anilinopyrimidines and -triazines
Argyrios G. Arvanitis,
Paul J. Gilligan,
Robert J. Chorvat,
Robert S. Cheeseman,
Thomas E. Christos,
Rajagopal Bakthavatchalam,
James P. Beck,
Anthony J. Cocuzza,
Frank W. Hobbs,
Richard G. Wilde,
Charles Arnold,
Dennis Chidester,
Matthew Curry,
Liqi He,
Andrea Hollis,
John Klaczkiewicz,
Paul J. Krenitsky,
Joseph P. Rescinito,
Everett Scholfield,
Steven Culp,
Errol B. De Souza,
Lawrence Fitzgerald,
Dimitri Grigoriadis,
S. William Tam,
Y. Nancy Wong,
Shiew-Mei Huang,
and
Helen L. Shen
[Full Article -
PDF] |
819-832
| Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies
C. Nicholas Hodge,
Paul E. Aldrich,
Zelda R. Wasserman,
Christina H. Fernandez,
Gregory A. Nemeth,
Argyrios Arvanitis,
Robert S. Cheeseman,
Robert J. Chorvat,
Engelbert Ciganek,
Thomas E. Christos,
Paul J. Gilligan,
Paul Krenitsky,
Everett Scholfield, and
Philip Strucely
[Full Article -
PDF] |
833-848
| Synthesis, Corticotropin-Releasing Factor Receptor Binding Affinity, and Pharmacokinetic Properties of Triazolo-, Imidazo-, and Pyrrolopyrimidines and -pyridines
Robert J. Chorvat,
Rajagopal Bakthavatchalam,
James P. Beck,
Paul J. Gilligan,
Richard G. Wilde,
Anthony J. Cocuzza,
Frank W. Hobbs,
Robert S. Cheeseman,
Matthew Curry,
Joseph P. Rescinito,
Paul Krenitsky,
Dennis Chidester,
Jerry A. Yarem,
John D. Klaczkiewicz,
C. Nicholas Hodge,
Paul E. Aldrich,
Zelda R. Wasserman,
Christine H. Fernandez,
Robert Zaczek,
Lawrence W. Fitzgerald,
Shiew-Mei Huang,
Helen L. Shen,
Y. Nancy Wong,
Ben M. Chien,
Check Y. Quon, and
Argyrios Arvanitis
[Full Article -
PDF] |
849-858
| Bisquaternary Ligands of the Common Allosteric Site of M2 Acetylcholine Receptors: Search for the Minimum Essential Distances between the Pharmacophoric Elements
Tamer Nassif-Makki,
Christian Tränkle,
Darius Zlotos,
Gesine Bejeuhr,
Antonella Cambareri,
Claudia Pfletschinger,
Evi Kostenis,
Klaus Mohr, and
Ulrike Holzgrabe
[Full Article -
PDF] |
859-867
| Synthesis and Biological Evaluation of 2',3'-Didehydro-2',3'-dideoxy-5- fluorocytidine (D4FC) Analogues: Discovery of Carbocyclic Nucleoside Triphosphates with Potent Inhibitory Activity against HIV-1 Reverse Transcriptase
Junxing Shi,
J. Jeffrey McAtee,
Susan Schlueter Wirtz,
Phillip Tharnish,
Amy Juodawlkis,
Dennis C. Liotta, and
Raymond F. Schinazi
[Full Article -
PDF] |
868-881
| Prediction of the Binding Free Energies of New TIBO-like HIV-1 Reverse Transcriptase Inhibitors Using a Combination of PROFEC, PB/SA, CMC/MD, and Free Energy Calculations
Mats A. L. Eriksson,
Jed Pitera, and
Peter A. Kollman
[Full Article -
PDF] |
882-895
| Synthesis and Pharmacology of Site-Specific Cocaine Abuse Treatment Agents: 2-(Aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane Dopamine Uptake Inhibitors
Howard M. Deutsch,
David M. Collard,
Liang Zhang,
Kikue S. Burnham,
Abhay K. Deshpande,
Stephan G. Holtzman, and
Margaret M. Schweri
[Full Article -
PDF] |
896-902
| Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase
Wensheng Lang,
Ce Qin,
Sonyuan Lin,
Atmaram D. Khanolkar,
Andreas Goutopoulos,
Pusheng Fan,
Khaled Abouzid,
Zhaoxing Meng,
Diane Biegel, and
Alexandros Makriyannis
[Full Article -
PDF] |
903-909
| Design, Synthesis, and Structure-Activity Relationships of Acetylene-Based Histamine H3 Receptor Antagonists
Syed M. Ali,
Clark E. Tedford,
Rosilyn Gregory,
Michael K. Handley,
Stephen L. Yates,
Walter W. Hirth, and
James G. Phillips
[Full Article -
PDF] |
910-919
| Identification of Novel Classes of Protein Kinase Inhibitors Using Combinatorial Peptide Chemistry Based on Functional Genomics Knowledge
Thomas J. Lukas,
Salida Mirzoeva,
Urszula Slomczynska, and
D. Martin Watterson
[Full Article -
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920-934
| Selective, Tight-Binding Inhibitors of Integrin  4 1 That Inhibit Allergic Airway Responses
Ko-chung Lin,
Humayun S. Ateeq,
Sherry H. Hsiung,
Lillian T. Chong,
Craig N. Zimmerman,
Alfredo Castro,
Wen-cherng Lee,
Charles E. Hammond,
Sandhya Kalkunte,
Ling-Ling Chen,
R. Blake Pepinsky,
Diane R. Leone,
Andrew G. Sprague,
William M. Abraham,
Alan Gill,
Roy R. Lobb, and
Steven P. Adams
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BRIEF ARTICLES
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935-940
| Synthesis and Dopaminergic Properties of Benzo-Fused Analogues of Quinpirole and Quinelorane
Martin K.-H. Doll,
David E. Nichols,
Jason D. Kilts,
Cassandra Prioleau,
Cindy P. Lawler,
Mechelle M. Lewis, and
Richard B. Mailman
[Full Article -
PDF] |
941-946
| Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines
Krishnamurthy Shyam,
Philip G. Penketh,
Maxim Shapiro,
Michael F. Belcourt,
Regina H. Loomis,
Sara Rockwell, and
Alan C. Sartorelli
[Full Article -
PDF] |